Boston Lyric Opera is set to open its new season with Mozart’s “Mitridate, Re di Ponto,” an early opera seria triumph.

The work, which will be presented between Sept. 13 and 15 at the Emerson Cutler Majestic Theatre, will showcase Lawrence Brownlee in the title role. The production will also include soprano Brenda Rae in the role of Mitridate’s fiancée Aspasia, Vanessa Goikoetxea, and John Holiday as siblings Sifare as Farnace, and Charles Sy as Marzio.

Finally, the cast also includes the talents of BLO Emerging Artists Angela Yam as Ismene and Alexis Peart as Arbate.

James Darrah will direct the opera and Music Director David Angus, who marks his 15th season with BLO, will conduct.

BLO Artistic Director Nina Yoshida Nelsen said, “Bringing ‘Mitridate’ is a significant artistic achievement for the company. Because of the demanding nature of Mozart’s vocal parts, it requires a unique confluence of extraordinary artists. Our production highlights the opera’s musical brilliance, which includes some Olympian vocal parts. Challenging coloratura passages, wide vocal ranges, and expressive recitatives demand technical precision and dramatic interpretation. The story’s intensity covers a terrain of emotions from love and jealousy, to longing and forgiveness.”

The production will be recorded for later audio broadcast as part of CRB Classical 99.5’s “In Concert” series.